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Research Domain Criteria

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Research Domain Criteria 2.3

The Research Domain Criteria (RDoC) Collection v2.3 was published on 2025-05-19. RDoC Distribution v2.3 includes 7521 individuals, 5243 of whom have at least one biosample on record at the biorepository. In addition to case/control studies, the RDOC Collection includes 4 family studies, 1 of which includes families that are large and/or multigenerational.

Standard Data & Documentation

  • Distribution Bundle [ or ]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
  • Study Descriptions.
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Additional Data Files

Clinical Instruments

Other

  • Study 70 Phenotypic Data [ or ] Includes patient diagnoses and information about current and past alcohol and substance abuse, anxiety and eating disorders, and ADHD
  • Lists 200+ publications attributed to study 70
  • Study 70 Age Months Phen [ or ]

Clinical Instruments

Other

  • NDA linking GUIDs [ or ] Study 120 was also submitted to the RDoCdb. This file provides linking IDs per subject per instrument submitted to NDA, and age in months per subject.
  • Study 120 Age Months Phen [ or ]

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Clinical Instruments

Other

  • Study 147 Extended Diagnosis File [ or ]

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 70 — Consortium for Neuropsychiatric Phenomics

  • Study 70 Phenotypic Data [ or ] Includes patient diagnoses and information about current and past alcohol and substance abuse, anxiety and eating disorders, and ADHD
  • Lists 200+ publications attributed to study 70
  • Study 70 Age Months Phen [ or ]

Study 120 — RDoC Constructs: Neural Substrates, Heritability, and Relation to Psychopathology

  • NDA linking GUIDs [ or ] Study 120 was also submitted to the RDoCdb. This file provides linking IDs per subject per instrument submitted to NDA, and age in months per subject.
  • Study 120 Age Months Phen [ or ]

Study 147 — Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria

  • Study 147 Extended Diagnosis File [ or ]